Development of a peptide-containing chewing gum as a sustained release antiplaque antimicrobial delivery system


Faraj J. A. , Dorati R., Schoubben A., Worthen D., Selmin F., Capan Y. , ...More

AAPS PHARMSCITECH, vol.8, no.1, 2007 (Journal Indexed in SCI) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 8 Issue: 1
  • Publication Date: 2007
  • Doi Number: 10.1208/pt0801026
  • Title of Journal : AAPS PHARMSCITECH

Abstract

The objective of this study was to characterize the stability of KSL-W, an antimicrobial decapeptide shown to inhibit the growth of oral bacterial strains associated with caries development and plaque formation, and its potential as an antiplaque agent in a chewing gum formulation. KSL-W formulations with or without the commercial antibacterial agent cetylpyridinium chloride (CPC) were prepared. The release of KSL-W from the gums was assessed in vitro using a chewing gum apparatus and in vivo by a chew-out method. A reverse-phase high-performance liquid chromatography method was developed for assaying KSL-W. Raw material stability and temperature and pH effects on the stability of KSL-W solutions and interactions of KSL-W with tooth-like material, hydroxyapatite discs, were investigated.