In vitro immunomodulatory activity of verbascoside from Nepeta ucrainica L.

Akbay P., Çalış İ., Undeger U., Basaran N., Basaran A.

PHYTOTHERAPY RESEARCH, vol.16, no.6, pp.593-595, 2002 (SCI-Expanded) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 16 Issue: 6
  • Publication Date: 2002
  • Doi Number: 10.1002/ptr.990
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Page Numbers: pp.593-595
  • Hacettepe University Affiliated: Yes


Nepeta ucrainica L. is used as a herbal tea in Kazakhistan. Phytochemical investigations of the aerial parts of the plant resulted in the isolation of verbascoside (1) and 1,5,9-epi-deoxyloganic acid (2). The structures of the compounds were elucidated by spectral (UV, IR, H-1-NMR and C-13-NMR) methods and HPLC analysis. The in vitro immunomodulatory activity of verbascoside was investigated by assessing neutrophil function; chemotaxis and intracellular killing activity. Verbascoside showed an increased chemotactic activity in all doses applied compared with the medium used as a negative control and had a positive effect on respiratory burst of neutrophils, but there was an opposite effect with increasing doses, pointing to a possible suppression of neutrophil intracellular killing activity. Copyright (C) 2002 John Wiley Sons, Ltd.