Synthesis and X-ray crystal structure of the calcium channel antagonist: dimethyl 1,4-dihydro-2,6-dimethyl-4-[4 '-(4H-4-oxo-1-benzopyran-2-yl)phenyl]-3,5-pyridine dicarboxylate


TUNCBILEK M. G. , Ozbey S. , KENDI E., YILDIRIM E., EROL K., ERTAN R.

FARMACO, cilt.54, ss.660-665, 1999 (SCI İndekslerine Giren Dergi) identifier identifier

Özet

The synthesis of the title compound via the Hantzsch method from 4'-flavone carboxaldehyde is described, and its molecular structure was determined by X-ray crystallography. The 1,4-dihydropyridine (1,4-DHP) ring adopts a boat conformation. The phenyl ring of the flavone is not exactly perpendicular to the DHP ring. Calcium antagonistic activity of this compound was evaluated in vitro by using BaCl2-stimulated rat ileum. (C) 1999 Elsevier Science S.A. All rights reserved.