Synthesis and X-ray crystal structure of the calcium channel antagonist: dimethyl 1,4-dihydro-2,6-dimethyl-4-[4 '-(4H-4-oxo-1-benzopyran-2-yl)phenyl]-3,5-pyridine dicarboxylate

TUNCBILEK, MÜNİP; Ozbey, SÜHEYLA; KENDI, E; YILDIRIM, E; EROL, K; ERTAN, R

doi:10.1016/s0014-827x(99)00076-2

Synthesis and X-ray crystal structure of the calcium channel antagonist: dimethyl 1,4-dihydro-2,6-dimethyl-4-[4 '-(4H-4-oxo-1-benzopyran-2-yl)phenyl]-3,5-pyridine dicarboxylate

Atıf İçin Kopyala

TUNCBILEK M. G., Ozbey S., KENDI E., YILDIRIM E., EROL K., ERTAN R.

FARMACO, cilt.54, sa.10, ss.660-665, 1999 (SCI-Expanded)

Yayın Türü: Makale / Tam Makale
Cilt numarası: 54 Sayı: 10
Basım Tarihi: 1999
Doi Numarası: 10.1016/s0014-827x(99)00076-2
Dergi Adı: FARMACO
Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
Sayfa Sayıları: ss.660-665
Hacettepe Üniversitesi Adresli: Evet

Özet

The synthesis of the title compound via the Hantzsch method from 4'-flavone carboxaldehyde is described, and its molecular structure was determined by X-ray crystallography. The 1,4-dihydropyridine (1,4-DHP) ring adopts a boat conformation. The phenyl ring of the flavone is not exactly perpendicular to the DHP ring. Calcium antagonistic activity of this compound was evaluated in vitro by using BaCl2-stimulated rat ileum. (C) 1999 Elsevier Science S.A. All rights reserved.