On 23 October 2011, a very strong earthquake with a magnitude of Mw = 7.2 shook Eastern Anatolia, and tremors were felt up to 500 km from the epicentre. In this study, we present an early analysis of ionospheric disturbance due to this earthquake using Global Positioning Satellite-Total Electron Content (GPS-TEC). The variability with respect to average quiet day TEC (AQDT) and variability between the consecutive days are measured with symmetric Kullback-Leibler divergence (SKLD). A significant variability in total electron content (TEC) is observed from the GPS stations in the 150 km neighbourhood of the epicentre eight and nine days prior to the earthquake. An ionospheric disturbance is observed from GPS stations even more than 1,000 km to the epicentre, especially those on the North Anatolian fault (NAF). The present results support the existence of lithosphere-atmosphere-ionosphere coupling (LAIC) associated with Van, Turkey earthquake.