The Role of Exercise, Diet, and Cytokines in Preventing Obesity and Improving Adipose Tissue

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Atakan M. M., Koşar Ş. N., Güzel Y., Tin H. T., Yan X.

NUTRIENTS, cilt.13, sa.5, 2021 (SCI-Expanded) identifier identifier identifier

  • Yayın Türü: Makale / Derleme
  • Cilt numarası: 13 Sayı: 5
  • Basım Tarihi: 2021
  • Doi Numarası: 10.3390/nu13051459
  • Dergi Adı: NUTRIENTS
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus, Agricultural & Environmental Science Database, BIOSIS, CAB Abstracts, CINAHL, EMBASE, Food Science & Technology Abstracts, MEDLINE, Veterinary Science Database, Directory of Open Access Journals
  • Anahtar Kelimeler: obesity, adipose tissue, exercise, diet, cytokines, BETA-AMINOISOBUTYRIC ACID, ACTIVATED PROTEIN-KINASE, INDUCED WEIGHT-LOSS, LOW-FAT DIET, MESSENGER-RNA EXPRESSION, GREATER IRISIN RESPONSE, HIGH-INTENSITY EXERCISE, NECROSIS-FACTOR-ALPHA, HUMAN SKELETAL-MUSCLE, C-REACTIVE PROTEIN
  • Hacettepe Üniversitesi Adresli: Evet

Özet

The prevalence of obesity continues to rise worldwide despite evidence-based public health recommendations. The promise to adopt a healthy lifestyle is increasingly important for tackling this global epidemic. Calorie restriction or regular exercise or a combination of the two is accepted as an effective strategy in preventing or treating obesity. Furthermore, the benefits conferred by regular exercise to overcome obesity are attributed not only to reduced adiposity or reduced levels of circulating lipids but also to the proteins, peptides, enzymes, and metabolites that are released from contracting skeletal muscle or other organs. The secretion of these molecules called cytokines in response to exercise induces browning of white adipose tissue by increasing the expression of brown adipocyte-specific genes within the white adipose tissue, suggesting that exercise-induced cytokines may play a significant role in preventing obesity. In this review, we present research-based evidence supporting the effects of exercise and various diet interventions on preventing obesity and adipose tissue health. We also discuss the interplay between adipose tissue and the cytokines secreted from skeletal muscle and other organs that are known to affect adipose tissue and metabolism.