Neuroprotection Mediated by Upregulation of Endothelial Nitric Oxide Synthase in Rho-Associated, Coiled-Coil-Containing Kinase 2 Deficient Mice

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Hiroi Y., Noma K., Kim H., Sladojevic N., Tabit C. E., Li Y., ...Daha Fazla

CIRCULATION JOURNAL, cilt.82, sa.4, ss.1195-1207, 2018 (SCI-Expanded) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 82 Sayı: 4
  • Basım Tarihi: 2018
  • Doi Numarası: 10.1253/circj.cj-17-0732
  • Dergi Adı: CIRCULATION JOURNAL
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Sayfa Sayıları: ss.1195-1207
  • Hacettepe Üniversitesi Adresli: Evet

Özet

Background: Rho-associated kinases (ROCK1 and ROCK2) are important regulators of the actin cytoskeleton and endothelial nitric oxide synthase (eNOS). Because the phosphorylation of eukaryotic elongation factor-1A1 (eEF1A1) by ROCK2 is critical for eNOS expression, we hypothesized that this molecular pathway may play a critical role in neuroprotection following focal cerebral ischemia.