Neuroprotection Mediated by Upregulation of Endothelial Nitric Oxide Synthase in Rho-Associated, Coiled-Coil-Containing Kinase 2 Deficient Mice


Hiroi Y. , Noma K., Kim H., Sladojevic N., Tabit C. E. , Li Y., ...Daha Fazla

CIRCULATION JOURNAL, cilt.82, ss.1195-1207, 2018 (SCI İndekslerine Giren Dergi) identifier identifier identifier

  • Cilt numarası: 82 Konu: 4
  • Basım Tarihi: 2018
  • Doi Numarası: 10.1253/circj.cj-17-0732
  • Dergi Adı: CIRCULATION JOURNAL
  • Sayfa Sayıları: ss.1195-1207

Özet

Background: Rho-associated kinases (ROCK1 and ROCK2) are important regulators of the actin cytoskeleton and endothelial nitric oxide synthase (eNOS). Because the phosphorylation of eukaryotic elongation factor-1A1 (eEF1A1) by ROCK2 is critical for eNOS expression, we hypothesized that this molecular pathway may play a critical role in neuroprotection following focal cerebral ischemia.