This study aims to analyze the relationship/effect of a wide range of individual factors with/on menopausal symptom severity (MSS) and menopause-specific quality of life (MSQoL) in rural Turkish women. This cross-sectional study included rural perimenopausal/postmenopausal women. Demographic (age, marital status, and education and employment status), physical (body weight and height), medical (chronic disease status), obstetric (number of gravidas), and menopausal characteristics (menopausal nature, perception of menopause, and menopausal stage), physical activity level, anxiety and depressive symptom levels, MSS, and MSQoL of the participants were assessed. The relationships between MSS/MSQoL and all individual characteristics were examined by correlation analyses. In addition, MSS and MSQoL were compared between various categories using independent-groups t tests and variance analyses. Statistical significance level was set at p <0.05. A total of 245 women (mean age 56.64 +/- 6.59 years) were included in the study. It was found that marital status, body mass index, presence of chronic disease, the number of gravidas, perception of menopause, and anxiety and depressive symptom levels were associated with MSS and MSQoL (p < 0.05). On the other hand, symptom severity and QoL did not change according to the level of education, employment status, menopausal nature, menopausal stage, and physical activity level (p > 0.05). MSS and MSQoL in rural women may be associated or affected by a wide range of individual characteristics, and this relationship or influence differs from the urban women literature at some points. Further studies are needed to illuminate the menopausal process in rural areas and compare rural and urban results.