Induction of apoptotic cell death in HL-60 cells by acteoside, a phenylpropanoid glycoside


Inoue M., Sakuma Z., Ogihara Y., Saracoglu İ.

BIOLOGICAL & PHARMACEUTICAL BULLETIN, cilt.21, ss.81-83, 1998 (SCI İndekslerine Giren Dergi) identifier identifier identifier

  • Cilt numarası: 21 Konu: 1
  • Basım Tarihi: 1998
  • Doi Numarası: 10.1248/bpb.21.81
  • Dergi Adı: BIOLOGICAL & PHARMACEUTICAL BULLETIN
  • Sayfa Sayıları: ss.81-83

Özet

Acteoside, a phenylpropanoid glycoside with anti-oxidative activity, induced cell death in promyelocytic leukemia HL-60 cells with an IC50 value of 26.7 mu M. Analysis of extracted DNA on agarose gel electrophoresis revealed that acteoside induced the internucleosomal breakdown of chromatin DNA characteristic of apoptosis. Apoptosis-specific DNA fragmentation was clearly detectable 4 h after treatment with acteoside and was independent of the cell cycle phase. These data indicate that acteoside induces apoptosis in HL-60 cells.