Diuretic renal scintigraphy (DRS) is used worldwide for evaluation of kidney functions, diagnosis of pelvic or ureteric obstruction and documentation of the effectiveness of surgical interventions. Although it is a basic imaging procedure of nuclear medicine, there is a wide range of variability in acquisition procedures. Nuclear medicine physicians have the opportunity to modify DRS imaging protocols according to specific clinical problem or question. This plasticity requires readers experience. Interpretation of dynamic images and the quantitative parameters entails knowledge of physiology and pathophysiology of kidneys and collective system. Standardization of patient preparation, imaging protocols and reporting not only would increase the readers' confidence but also would increase the reliability of DRS. (C) 2021 Published by Elsevier Inc.