Purpose: The aim of this study is to analyze Turkey's blood collection efficiency at the regional level between 2018 and 2021 and discuss managerial implications. Design/methodology/approach: The authors utilize data envelopment analysis (DEA) to evaluate the efficiency scores of the 18 regions for which the Turkish Red Crescent is responsible. The data set is obtained from the General Directorate of Blood Services in the Turkish Red Crescent. Findings: The results reveal that the efficient regions over the years did not substantially change, and regions that were consistently efficient for a four-year period are identified. Another finding is that COVID-19 did not affect the blood collection efficiency of the regions. Moreover, the findings illustrate that concentrating on the operations would contribute more to the blood collection efficiency than changing the scale size. Furthermore, the authors observe that the service population is by far the most important variable in determining the efficiency of the regions. Originality/value: In this study, the authors present a multi-dimensional perspective on the performance evaluation of blood collection operations. In addition, the authors present blood bank managers' feedback on the performance evaluation model, outlining managerial implications. Furthermore, the authors explore the effects of the pandemic on blood collection in Turkey and illustrate the changes in efficiency throughout a distinct period that incorporates the pandemic. The study would provide a guide for blood bank managers to improve the performance of their organizations.