Migraine is a major health and disability problem. Results of existing pharmacological treatment Options have been unsatisfactory. Acupuncture is a non-pharmacological treatment for pain and has been found to be more effective for treating migraine than preventive migraine medicines. The way acupuncture modulates brain structures has been demonstrated by PET and functional MM. studies. Acupuncture has a significant vasodilatory effect on the radial artery diameter of migraine patients which interacts with the mechanisms of pain. Acupuncture also effects cell secretion, signalling and afferent sensory input, and the activity of norepinephrine, angiotensin II, serotonin, enkephalin, beta-endorphin and glutamate. Acupuncture has a strong analgesic effect and should be widely used in migraine treatment.