Antimicrobial resistance and epidemiological patterns of<i> Streptococcus</i><i> pyogenes</i> in Türkiye

ÜNÜBOL N., Caglayan N., Cebeci S., Besli Y., SANCAK B., YURTTUTAN UYAR N., ...More

JOURNAL OF INFECTION AND PUBLIC HEALTH, no.2, 2025 (SCI-Expanded) identifier identifier

  • Publication Type: Article / Article
  • Publication Date: 2025
  • Doi Number: 10.1016/j.jiph.2024.102633
  • Journal Name: JOURNAL OF INFECTION AND PUBLIC HEALTH
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus, PASCAL, CAB Abstracts, Food Science & Technology Abstracts, MEDLINE, Veterinary Science Database, Directory of Open Access Journals
  • Hacettepe University Affiliated: Yes

Abstract

Background: Drug-resistant Group A beta-hemolytic streptococci remain significant infectious agents globally. This study investigated the major S. pyogenes strains responsible for infections in T & uuml;rkiye and their susceptibility to beta-lactam and macrolide antibiotics. Methods: We determined the minimum inhibitory concentration using the penicillin gradient test and performed emm typing and DNA fingerprinting via pulsed-field gel electrophoresis (PFGE) to analyze the clonal spread of 92 S. pyogenes strains isolated from two hospitals in T & uuml;rkiye between 2020 and 2022. Results: Our findings revealed the predominant S. pyogenes strains causing infections in the population and provided insights into the epidemiological relatedness of these drug-resistant strains. This study also evaluated the correlation between emm typing and PFGE in tracking S. pyogenes epidemiology. In this study, the current resistance patterns of S. pyogenes strains in T & uuml;rkiye identified erythromycin resistance in a few strains, but no resistance to penicillin was detected. Conclusions: This study revealed that emm types 1, 12 and 89 as S. pyogenes strain genotypes were responsible for epidemic infections in T & uuml;rkiye. PFGE genotyping and emm typing were found to provide better phylogenetic classification in the investigation of S. pyogenes epidemiology. (c) 2024 The Authors. Published by Elsevier Ltd on behalf of King Saud Bin Abdulaziz University for Health Sciences. This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/ 4.0/).