GC-MS Based Metabolic Profiling of Parkinson's Disease with Glutathione S-transferase M1 and T1 Polymorphism in Tunisian Patients

Rebai A., REÇBER T., NEMUTLU E., Chbili C., KURBANOĞLU S., KIR S., ...Daha Fazla

COMBINATORIAL CHEMISTRY & HIGH THROUGHPUT SCREENING, cilt.23, sa.10, ss.1041-1048, 2020 (SCI-Expanded) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 23 Sayı: 10
  • Basım Tarihi: 2020
  • Doi Numarası: 10.2174/1386207323666200428082815
  • Dergi Adı: COMBINATORIAL CHEMISTRY & HIGH THROUGHPUT SCREENING
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus, Agricultural & Environmental Science Database, BIOSIS, Biotechnology Research Abstracts, CAB Abstracts, Chemical Abstracts Core, EMBASE, MEDLINE, Veterinary Science Database
  • Sayfa Sayıları: ss.1041-1048
  • Anahtar Kelimeler: Glutathione S-transferases polymorphism, metabolomic profile, metabolites, oxidative stress, Parkinson's disease, Tunisian patient, HUMAN BRAIN, BIOMARKERS, LACTATE, ASSOCIATION, ACID, COHORT
  • Hacettepe Üniversitesi Adresli: Evet

Özet

Aim and Objective: Parkinson's disease (PD) is the second most common neurodegenerative disease. It is a multifactorial disorder (caused by aging, environmental, and genetic factors). Metabolomics can help explore the biomarker profiles for aging. Recent studies showed an association between the glutathione S-transferases (GSTs) polymorphisms and PD risk. The purpose of this study was to evaluate the association of this genetic polymorphism and the metabolomic profile in PD Tunisian patients, in order to identify effective biomarkers in the genetic differentiation.