GC-MS Based Metabolic Profiling of Parkinson's Disease with Glutathione S-transferase M1 and T1 Polymorphism in Tunisian Patients

Rebai A., REÇBER T., NEMUTLU E., Chbili C., KURBANOĞLU S., KIR S., ...More

COMBINATORIAL CHEMISTRY & HIGH THROUGHPUT SCREENING, vol.23, no.10, pp.1041-1048, 2020 (SCI-Expanded) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 23 Issue: 10
  • Publication Date: 2020
  • Doi Number: 10.2174/1386207323666200428082815
  • Journal Name: COMBINATORIAL CHEMISTRY & HIGH THROUGHPUT SCREENING
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus, Agricultural & Environmental Science Database, BIOSIS, Biotechnology Research Abstracts, CAB Abstracts, Chemical Abstracts Core, EMBASE, MEDLINE, Veterinary Science Database
  • Page Numbers: pp.1041-1048
  • Keywords: Glutathione S-transferases polymorphism, metabolomic profile, metabolites, oxidative stress, Parkinson's disease, Tunisian patient, HUMAN BRAIN, BIOMARKERS, LACTATE, ASSOCIATION, ACID, COHORT
  • Hacettepe University Affiliated: Yes

Abstract

Aim and Objective: Parkinson's disease (PD) is the second most common neurodegenerative disease. It is a multifactorial disorder (caused by aging, environmental, and genetic factors). Metabolomics can help explore the biomarker profiles for aging. Recent studies showed an association between the glutathione S-transferases (GSTs) polymorphisms and PD risk. The purpose of this study was to evaluate the association of this genetic polymorphism and the metabolomic profile in PD Tunisian patients, in order to identify effective biomarkers in the genetic differentiation.