Inhibiting inducible nitric oxide synthase with rutin reduces renal ischemia/reperfusion injury

Creative Commons License

Korkmaz A., KOLANKAYA D.

CANADIAN JOURNAL OF SURGERY, vol.56, no.1, pp.6-14, 2013 (SCI-Expanded) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 56 Issue: 1
  • Publication Date: 2013
  • Doi Number: 10.1503/cjs.004811
  • Journal Name: CANADIAN JOURNAL OF SURGERY
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Page Numbers: pp.6-14
  • Hacettepe University Affiliated: Yes

Abstract

Background: Nitric oxide (NO) seems to play an important role during renal ischemia/reperfusion (I/R) injury. We investigated whether rutin inhibits inducible nitric oxide synthase (iNOS) and reduces 3-nitrotyrosine (3-NT) formation in the kidneys of rats during I/R.