Inhibiting inducible nitric oxide synthase with rutin reduces renal ischemia/reperfusion injury

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Korkmaz A., KOLANKAYA D.

CANADIAN JOURNAL OF SURGERY, vol.56, no.1, pp.6-14, 2013 (SCI-Expanded, Scopus)

• Publication Type: Article / Article
• Volume: 56 Issue: 1
• Publication Date: 2013
• Doi Number: 10.1503/cjs.004811
• Journal Name: CANADIAN JOURNAL OF SURGERY
• Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
• Page Numbers: pp.6-14
• Open Archive Collection: AVESIS Open Access Collection
• Hacettepe University Affiliated: Yes

Abstract

Background: Nitric oxide (NO) seems to play an important role during renal ischemia/reperfusion (I/R) injury. We investigated whether rutin inhibits inducible nitric oxide synthase (iNOS) and reduces 3-nitrotyrosine (3-NT) formation in the kidneys of rats during I/R.