Four different dimethyltin(IV) complexes of Schiff bases derived from 2-amino-3-hydroxypyridine and different substituted salicylaldehydes have been synthesized. The compounds, with the general formula [Me2Sn(2-OArCH=NC5H3NO)], where Ar = -C6H3(5-CH3) [Me2SnL1], -C6H3(5-NO2) [Me2SnL2], -C6H2(3,5-Cl-2) [Me2SnL3], and -C6H2(3,5-l(2)) [Me2SnL4], were characterized by IR. NMR (H-1 and C-13), mass spectroscopy and elemental analysis. Me2SnL3 was also characterized by X-ray diffraction analysis and shows a fivefold C2NO2 coordination with distorted square pyramidal geometry. H3C-Sn-CH3 angles in the complexes were calculated using Lockhart's equations with the (1)J(Sn-117/119-C-13) and (2)J(Sn-117/119-H-1) values (from the H-1-NMR and C-13-NMR spectra). The in vitro antibacterial and antifungal activities of dimethyltin(IV) complexes were also investigated. (C) 2008 Elsevier B.V. All rights reserved.