Management of invasive candidal infections: Results of a prospective, randomized, multicenter study of fluconazole versus amphotericin B and review of the literature
Clinical Infectious Diseases, vol.23, no.5, pp.964-972, 1996 (Scopus)
- Publication Type: Article / Article
- Volume: 23 Issue: 5
- Publication Date: 1996
- Doi Number: 10.1093/clinids/23.5.964
- Journal Name: Clinical Infectious Diseases
- Journal Indexes: Scopus
- Page Numbers: pp.964-972
- Hacettepe University Affiliated: Yes
Abstract
We conducted a prospective, randomized, multicenter study comparing fluconazole and amphotericin B in the treatment of candidal infections. One hundred and sixty-four patients (60 of whom were neutropenic) with documented or presumed invasive candidiasis were assigned to treatment with either fluconazole (400 mg daily) or amphotericin B (25-50 mg daily; 0.67 mg/kg daily for neutropenic patients). Clinical response and survival rates were assessed at 48 hours, after 5 days, and at the end of therapy. Overall response rates to fluconazole and amphotericin B were similar (66% and 64%, respectively). There were no differences in response as related to site of infection, pathogen, time to defervescence, relapse, or survival rates between the groups. Adverse effects were more frequent with amphotericin B (35%) than with fluconazole (5%; P < .0001). The results of this study confirm that fluconazole is as effective as but better tolerated than amphotericin B in the treatment of candidal infections.