Musculoskeletal pain may be a symptom of progressive neuro-muscular diseases. The purpose of this research was to study the intensity and location of musculoskeletal pain in progressive neuro-muscular diseases, its impact on daily activities, and the results of a combined physiotherapy program. Thirty-four patients with different types of neuro-muscular diseases and musculoskeletal pain were included in the study. Pain intensity and activity levels were evaluated using visual analogue scales. After the initial evaluation, subjects underwent a supervised therapy program for 8 weeks and subsequently, they were followed for 6 months of home program. Supervised therapy program was performed 3 consecutive days a week. The therapy program consisted of range of motion exercises, stretching exercises, functional mobility training and energy conservation techniques (walking aids, orthoses, etc.). Pain intensity and the amount of difficulty while performing some activities of daily living decreased significantly at the end of the therapy program (p < 0.05). Pain intensity and activity improvement were correlated (p < 0.05).