Copy For Citation
Vargel I., Canter H. I., Kucukguven A., Aydin A., Ozgur F.
The Cleft palate-craniofacial journal : official publication of the American Cleft Palate-Craniofacial Association, vol.59, no.5, pp.637-643, 2022 (SCI-Expanded)
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Publication Type:
Article / Article
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Volume:
59
Issue:
5
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Publication Date:
2022
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Doi Number:
10.1177/10556656211019621
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Journal Name:
The Cleft palate-craniofacial journal : official publication of the American Cleft Palate-Craniofacial Association
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Journal Indexes:
Science Citation Index Expanded (SCI-EXPANDED), Scopus, CAB Abstracts, CINAHL, Educational research abstracts (ERA), EMBASE, Linguistics & Language Behavior Abstracts, MEDLINE, Veterinary Science Database
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Page Numbers:
pp.637-643
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Keywords:
ALX gene, cleft lip, cleft palate, facial clefts, frontonasal dysplasia, hypertelorism, median cleft, CNS STRUCTURAL ANOMALIES, MENTAL-RETARDATION, EYELID COLOBOMAS, EAR ANOMALIES, MACROBLEPHARON, HYPERTELORISM, MACROSTOMIA, DYSOSTOSIS, MUTATIONS, DEFECTS
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Hacettepe University Affiliated:
Yes
Abstract
Aim: The term frontonasal dysplasia (FND) represents a spectrum of anomalies and its genetics have not been well defined. Recently, the critical role of the aristaless-like homeobox (ALX) gene family on the craniofacial development has been discovered. In the present study, we aimed to propose a systematic surgical treatment plan for the ALX-related FNDs according to the genotypic classification as well as demonstrating their clinical characteristics to help surgeons diagnose the underlying pathology accurately.