Folding and self-assembly of a small heterotetramer

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YAŞAR F., SIERADZAN A. K., HANSMANN U. H. E.

JOURNAL OF CHEMICAL PHYSICS, cilt.140, sa.10, 2014 (SCI-Expanded, Scopus)

• Yayın Türü: Makale / Tam Makale
• Cilt numarası: 140 Sayı: 10
• Basım Tarihi: 2014
• Doi Numarası: 10.1063/1.4868140
• Dergi Adı: JOURNAL OF CHEMICAL PHYSICS
• Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
• Açık Arşiv Koleksiyonu: AVESİS Açık Erişim Koleksiyonu
• Hacettepe Üniversitesi Adresli: Evet

Özet

Designed miniproteins offer a possibility to study folding and association of protein complexes, both experimentally and in silico. Using replica exchange molecular dynamics and the coarse-grain UNRES force field, we have simulated the folding and self-assembly of the heterotetramer BBAThet1, comparing it with that of the homotetramer BBAT1 which has the same size and beta beta alpha-fold. For both proteins, association of the tetramer precedes and facilitates folding of the individual chains. (C) 2014 AIP Publishing LLC.