Monosomy 7 mosaicism in metastatic choroidal melanoma
CANCER GENETICS AND CYTOGENETICS, vol.177, no.1, pp.70-72, 2007 (SCI-Expanded, Scopus)
- Publication Type: Article / Article
- Volume: 177 Issue: 1
- Publication Date: 2007
- Doi Number: 10.1016/j.cancergencyto.2007.05.004
- Journal Name: CANCER GENETICS AND CYTOGENETICS
- Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
- Page Numbers: pp.70-72
- Hacettepe University Affiliated: Yes
Abstract
Uveal melanoma is the most common primary intraocular malignancy in adults. Several cytogenetic studies on uveal melanoma cells have revealed that the majority of these cells harbor alterations in chromosomes 3, 6, and 8. This report describes the results of cytogenetic analysis performed on a fresh choroidal melanoma tissue sample from a patient with cerebellar metastasis. Monosomy 7 mosaicism was observed. To our knowledge, monosomy 7 has not been reported in patients with uveal melanoma. We suggest that observation of monosomy 7 may be related to an aggressive clinical behavior and unusual cerebellar metastasis in uveal melanoma. Further data are necessary to define the exact role of monosomy 7 in the pathogenesis and evolution of uveal melanoma. (c) 2007 Elsevier Inc. All rights reserved.