Lung ultrasound scores within the first 3 days of life to predict respiratory outcomes

Aliyev F., KAYKI G., ANNAKKAYA KOÇYİĞİT T., İYİGÜN İ., YİĞİT Ş.

Pediatric Pulmonology, cilt.59, sa.3, ss.662-668, 2024 (SCI-Expanded) identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 59 Sayı: 3
  • Basım Tarihi: 2024
  • Doi Numarası: 10.1002/ppul.26804
  • Dergi Adı: Pediatric Pulmonology
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus, CAB Abstracts, MEDLINE, Veterinary Science Database
  • Sayfa Sayıları: ss.662-668
  • Anahtar Kelimeler: bronchopulmonary dysplasia, lung ultrasound, neonatal pulmonary medicine, respiratory outcomes
  • Hacettepe Üniversitesi Adresli: Evet

Özet

Backround: Lung ultrasound (LUS) is a rapid and simple method to evaluate preterm babies with respiratory distress. Lately, LUS has also been reported as an accurate predictor for bronchopulmonary dysplasia (BPD). Objectives: The aim of the study was to investigate the relationship between the LUS scores within the first 3 days of life and respiratory outcomes including the need and the duration of invasive mechanical ventilation, and development of BPD. Methods: It was a retrospective observational study. Preterm infants younger than 32 weeks were included at an academic tertiary Neonatal Intensive Care Unit between 2018 and 2023. LUS was performed within the first 3 days. Each lung was divided into three regions and defined as a score of 0 to 3 points; the total score was obtained by adding the six regional scores. LUS scores were noted in two groups as the highest and lowest scores. Statistical analyses were done to predict respiratory outcomes. Results: Total 218 patients were enrolled; 40, 17, and 18 infants had mild, moderate, and severe BPD, respectively. BPD did not develop in 143 patients. Within the first 3 days, the highest and lowest LUS scores significantly predicted moderate-to-severe BPD (p <.001) (area under receiver operating characteristic [ROC] curve, 0.684–0.913; area under ROC curve 0.647–0.902; respectively). High LUS scores were also related with the need of mechanical ventilation (p <.001). There was not a significant correlation between the duration of mechanical ventilation and the LUS scores. Regression analysis revealed that the highest LUS scores within the first 3 days of life, sepsis, and the presence of hemodynamically significant patent ductus arteriosus (hsPDA) were significantly associated with the severity of BPD. Conclusions: In preterm babies, the LUS scores were useful to predict BPD and the need of invasive ventilation in long term. However, it was not related with the length of invasive ventilation.