The Effects of Minocycline on the Hippocampus in Lithium-Pilocarpine Induced Status Epilepticus in Rat: Relations with Microglial/Astrocytic Activation and Serum MOB Level

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Bulduk E. B., KURT G., BARUN S., Aydemir O., Kiziltas M., Oktem M., ...More

TURKISH NEUROSURGERY, vol.29, no.1, pp.95-105, 2019 (SCI-Expanded) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 29 Issue: 1
  • Publication Date: 2019
  • Doi Number: 10.5137/1019-5149.jtn.22744-18.1
  • Journal Name: TURKISH NEUROSURGERY
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus, TR DİZİN (ULAKBİM)
  • Page Numbers: pp.95-105
  • Keywords: S100B, Astrocyte, Microglia, Minocycline, Seizure, BLOOD-BRAIN-BARRIER, MICROGLIAL ACTIVATION, GLIAL ACTIVATION, S100B PROTEIN, DENTATE GYRUS, CELL-DEATH, EPILEPSY, DISEASE, INFLAMMATION, ASTROCYTES
  • Hacettepe University Affiliated: Yes

Abstract

AIM: To investigate possible correlations between serum S100B levels and microglial/astrocytic activation in status epilepticus (SE) in lithium-pilocarpine-exposed rat hippocampi and whether serum S100B levels linearly reflect neuroinflammation. Additionally, to assess the effects of minocycline (M), an inhibitor of neuroinflammation.