Substituted 9-aryl-1,8-acridinedione derivatives and their effects on potassium channels


GÜNDÜZ M. G. , Dogan A. E. , ŞİMŞEK R. , Erol K., Safak C.

MEDICINAL CHEMISTRY RESEARCH, vol.18, no.4, pp.317-325, 2009 (Journal Indexed in SCI) identifier identifier

  • Publication Type: Article / Article
  • Volume: 18 Issue: 4
  • Publication Date: 2009
  • Doi Number: 10.1007/s00044-008-9129-9
  • Title of Journal : MEDICINAL CHEMISTRY RESEARCH
  • Page Numbers: pp.317-325

Abstract

In this study, 12 new 3,6-dimethyl-9-aryl-3,4,6,7-tetrahydroacridine-1,8(2H,5H,9H,10H)-diones derivatives were synthesized. Synthesis of the compounds was realized by the reaction of 5-methyl-1,3-cyclohexanedione, the appropriate aromatic aldehyde, and ammonium acetate in methanol. The structure of the compounds was elucidated by infrared (IR), H-1-nuclear magnetic resonance (NMR), C-13-NMR, mass spectroscopy, and elemental analysis. Functional effects of the compounds on vascular potassium channels and mechanism of phenylephrine-induced contractile responses were investigated in isolated rat aorta rings. Pinacidil was used as a standard potassium channel opener.