Substituted 9-aryl-1,8-acridinedione derivatives and their effects on potassium channels

GÜNDÜZ M. G., Dogan A. E., ŞİMŞEK R., Erol K., Safak C.

MEDICINAL CHEMISTRY RESEARCH, cilt.18, sa.4, ss.317-325, 2009 (SCI-Expanded) identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 18 Sayı: 4
  • Basım Tarihi: 2009
  • Doi Numarası: 10.1007/s00044-008-9129-9
  • Dergi Adı: MEDICINAL CHEMISTRY RESEARCH
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Sayfa Sayıları: ss.317-325
  • Anahtar Kelimeler: Potassium channel opening activity, Acridinedione, Pinacidil, BLADDER CONTRACTIONS, OPENING ACTIVITY, ATP, OPENERS, SERIES
  • Hacettepe Üniversitesi Adresli: Evet

Özet

In this study, 12 new 3,6-dimethyl-9-aryl-3,4,6,7-tetrahydroacridine-1,8(2H,5H,9H,10H)-diones derivatives were synthesized. Synthesis of the compounds was realized by the reaction of 5-methyl-1,3-cyclohexanedione, the appropriate aromatic aldehyde, and ammonium acetate in methanol. The structure of the compounds was elucidated by infrared (IR), H-1-nuclear magnetic resonance (NMR), C-13-NMR, mass spectroscopy, and elemental analysis. Functional effects of the compounds on vascular potassium channels and mechanism of phenylephrine-induced contractile responses were investigated in isolated rat aorta rings. Pinacidil was used as a standard potassium channel opener.