Research Information System
Cumhuriyet Dental Journal, vol.29, no.1, pp.111-121, 2026 (Scopus, TRDizin)
Objectives: Wound dressings protect the wound and accelerate the healing of ulcers. This study evaluated the role of distinct oral dressings in the wound healing of experimentally produced traumatic oral ulcers. Materials and Methods: The study included 45 male Sprague-Dawley rats, which were randomly divided into three groups: Group 1, Group 2 and control group. Two different wound dressings were applied: hyaluronic acid (Group 1) and a wound dressing composed of a combination of bioactive materials (Group 2). Tissue samples were taken in the 3rd, 7th, 14th days and evaluated histopathologically. The Kruskal-Wallis test was utilized for analyzing numerical data across groups, followed by post-hoc testing to compare differences across groups were analyzed through the Chi-square test. The Chi-square test was explored for categorical data. Results: Both wound dressings positively influenced the healing process compared with the control group. The hyaluronic acid-based dressing (Group 1) was associated with reduced ulceration scores and lower edema levels during the healing period. In contrast, the bioactive film dressing (Group 2) showed a more pronounced effect on early granulation tissue formation, particularly on day 3. Both treatment groups exhibited increased migration of polymorphonuclear leukocytes and mononuclear cells to the ulcer site during the early inflammatory phase. Conclusions: Both wound coverings positively affected the wound healing process by regulating distinct phases of healing.