Çağdaş Ayvaz D. N., Esenboga S., Akarsu A., Cevik N. N., Topeli A., Ozsurekci Y., ...More
JOURNAL OF MEDICAL VIROLOGY, vol.97, no.9, pp.1-10, 2025 (SCI-Expanded)
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Publication Type:
Article / Article
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Volume:
97
Issue:
9
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Publication Date:
2025
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Doi Number:
10.1002/jmv.70550
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Journal Name:
JOURNAL OF MEDICAL VIROLOGY
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Journal Indexes:
Science Citation Index Expanded (SCI-EXPANDED), Scopus, BIOSIS, CAB Abstracts, Veterinary Science Database
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Page Numbers:
pp.1-10
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Hacettepe University Affiliated:
Yes
Abstract
ABSTRACTCOVID‐19 has worse clinical outcomes in inborn errors of immunity (IEI) patients. We aimed to determine COVID‐19‐related hospitalization/ICU admission/mortality risk in patients with IEI. We included 62 COVID‐19 (29 children and 33 adults) in a referral center. F/M ratio was 0.94 with median age, 19 (8 months‐64 years) years. 53.2% had primary antibody deficiency. Hospitalization rate was 11/29 in children, 21/33 in adults and 7/11 in patients with combined immunodeficiency diseases. Myalgia was more common in adults compared to children (p = 0.013). Inpatients have more cough compared to outpatients (p = 0.002). D‐dimer and ferritin levels were higher in inpatients (p = 0.033 and p = 0.046, respectively). Cough (OR: 6.05; [95% CI: 1.76–20.74], p = 0.004) and immunoglobulin replacement therapy use in IEI (OR: 5.15; [95% CI: 1.46–18.11], p = 0.010) were related to hospitalization risk. Inpatients with intensive care unit (ICU) admission had higher ferritin levels (p = 0.02). 77.4% had at least one comorbidity like pulmonary (45.2%), autoimmune (38.7%), and gastrointestinal diseases (32.3%). ICU admission was high in agammaglobulinemia (40%) and immune dyseregulation (ID) (16.6%). An LRBA deficiency patient experienced MIS‐C (Multisystem Inflammatory Syndrome in Children) and another died. Eight patients, four in the present center, received convalescent plasma (X‐linked agammaglobulinemia [XLA] [n = 3], autosomal recessive agammaglobulinemia [n = 1], LRBA deficiency [n = 1], and CTLA4 deficiency [n = 1], CVID [n = 1], and STAT1 deficiency [n = 1]). Overall mortality was 6.5%, high in ID (16.6%), none in children. Higher D‐dimer and ferritin levels is associated with a higher hospitalization ratio‐ twice in adults compared to children. Overall mortality (6.5%) was about six times the general population with no mortality in children. A high ICU ratio in agammaglobulinemia, suggesting the importance of mucosal IgA in COVID‐19 defense. Convalescent plasma helps shorten hospitalization period in agammaglobulinemia.