NORTHERN CLINICS OF ISTANBUL, vol.7, no.6, pp.541-550, 2020 (Journal Indexed in ESCI)
Article / Article
Title of Journal :
NORTHERN CLINICS OF ISTANBUL
Apoptosis, oxidative stress, paracetamol, OXIDATIVE STRESS, ACETAMINOPHEN, MITOCHONDRIAL, DAMAGE, INHIBITION, COX-3, MICE
OBJECTIVE: Paracetamol is thought that it acts by inhibiting the central cyclooxygenase (COX) enzyme; its mechanism of action is still not fully explained. Although its most important side effect is hepatoxicity, it is thought to cause toxicity on the brain in recent years. The present study aims to investigate the treatment and toxic effects of low and high doses of paracetamol on the liver and brain.