Atıf İçin Kopyala
Oksuz E., Yaşar S., Erten R., Arihan O., Oto G.
NORTHERN CLINICS OF ISTANBUL, cilt.7, sa.6, ss.541-550, 2020 (ESCI)
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Yayın Türü:
Makale / Tam Makale
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Cilt numarası:
7
Sayı:
6
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Basım Tarihi:
2020
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Doi Numarası:
10.14744/nci.2020.54926
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Dergi Adı:
NORTHERN CLINICS OF ISTANBUL
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Derginin Tarandığı İndeksler:
Emerging Sources Citation Index (ESCI), Directory of Open Access Journals, TR DİZİN (ULAKBİM)
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Sayfa Sayıları:
ss.541-550
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Anahtar Kelimeler:
Apoptosis, oxidative stress, paracetamol, OXIDATIVE STRESS, ACETAMINOPHEN, MITOCHONDRIAL, DAMAGE, INHIBITION, COX-3, MICE
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Hacettepe Üniversitesi Adresli:
Evet
Özet
OBJECTIVE: Paracetamol is thought that it acts by inhibiting the central cyclooxygenase (COX) enzyme; its mechanism of action is still not fully explained. Although its most important side effect is hepatoxicity, it is thought to cause toxicity on the brain in recent years. The present study aims to investigate the treatment and toxic effects of low and high doses of paracetamol on the liver and brain.