Comparison of effects of high and low dose paracetamol treatment and toxicity on brain and liver in rats


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Oksuz E., Yaşar S., Erten R., Arihan O. , Oto G.

NORTHERN CLINICS OF ISTANBUL, vol.7, no.6, pp.541-550, 2020 (Journal Indexed in ESCI) identifier identifier

  • Publication Type: Article / Article
  • Volume: 7 Issue: 6
  • Publication Date: 2020
  • Doi Number: 10.14744/nci.2020.54926
  • Title of Journal : NORTHERN CLINICS OF ISTANBUL
  • Page Numbers: pp.541-550
  • Keywords: Apoptosis, oxidative stress, paracetamol, OXIDATIVE STRESS, ACETAMINOPHEN, MITOCHONDRIAL, DAMAGE, INHIBITION, COX-3, MICE

Abstract

OBJECTIVE: Paracetamol is thought that it acts by inhibiting the central cyclooxygenase (COX) enzyme; its mechanism of action is still not fully explained. Although its most important side effect is hepatoxicity, it is thought to cause toxicity on the brain in recent years. The present study aims to investigate the treatment and toxic effects of low and high doses of paracetamol on the liver and brain.