Comparison of effects of high and low dose paracetamol treatment and toxicity on brain and liver in rats

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Oksuz E., Yaşar S., Erten R., Arihan O., Oto G.

NORTHERN CLINICS OF ISTANBUL, cilt.7, sa.6, ss.541-550, 2020 (ESCI) identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 7 Sayı: 6
  • Basım Tarihi: 2020
  • Doi Numarası: 10.14744/nci.2020.54926
  • Dergi Adı: NORTHERN CLINICS OF ISTANBUL
  • Derginin Tarandığı İndeksler: Emerging Sources Citation Index (ESCI), Directory of Open Access Journals, TR DİZİN (ULAKBİM)
  • Sayfa Sayıları: ss.541-550
  • Anahtar Kelimeler: Apoptosis, oxidative stress, paracetamol, OXIDATIVE STRESS, ACETAMINOPHEN, MITOCHONDRIAL, DAMAGE, INHIBITION, COX-3, MICE
  • Hacettepe Üniversitesi Adresli: Evet

Özet

OBJECTIVE: Paracetamol is thought that it acts by inhibiting the central cyclooxygenase (COX) enzyme; its mechanism of action is still not fully explained. Although its most important side effect is hepatoxicity, it is thought to cause toxicity on the brain in recent years. The present study aims to investigate the treatment and toxic effects of low and high doses of paracetamol on the liver and brain.