mu-Opioid Receptor Gene (OPRM1) Polymorphisms A118G and C17T in Alcohol Dependence: A Turkish Sample

GÜREL Ş. C., AYHAN Y., Karaaslan C., Akel H., KARACA R. O., BABAOĞLU M. Ö., ...Daha Fazla

TURK PSIKIYATRI DERGISI, cilt.27, sa.2, ss.75-83, 2016 (SSCI) identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 27 Sayı: 2
  • Basım Tarihi: 2016
  • Doi Numarası: 10.5080/u12336
  • Dergi Adı: TURK PSIKIYATRI DERGISI
  • Derginin Tarandığı İndeksler: Social Sciences Citation Index (SSCI), Scopus, TR DİZİN (ULAKBİM)
  • Sayfa Sayıları: ss.75-83
  • Anahtar Kelimeler: Alcoholism, OPRM1, Single Nucleotide Polymorphisms, Genetics, SUBJECTIVE RESPONSES, MOLECULAR-BIOLOGY, OPIATE ADDICTION, DRUG-DEPENDENCE, MALE TWINS, ASSOCIATION, VARIANTS, CONSUMPTION, POPULATION, BEHAVIOR
  • Hacettepe Üniversitesi Adresli: Evet

Özet

Objectives: Previous investigations on opioid system genetics have identified polymorphisms of the OPRM1 gene expressing mu-opioid receptors to be significantly associated with some features of alcohol dependence (AD). In the present study, we evaluated the relationship between single nucleotide polymorphisms (SNP) in the OPRM1 gene, A118G (rs1799971, Asn40Asp) and C17T (rs1799972, Arg6Val), and AD diagnosis, level of alcohol consumption, and AD severity in a Turkish sample.