mu-Opioid Receptor Gene (OPRM1) Polymorphisms A118G and C17T in Alcohol Dependence: A Turkish Sample

GÜREL Ş. C., AYHAN Y., Karaaslan C., Akel H., KARACA R. O., BABAOĞLU M. Ö., ...More

TURK PSIKIYATRI DERGISI, vol.27, no.2, pp.75-83, 2016 (SSCI) identifier identifier

  • Publication Type: Article / Article
  • Volume: 27 Issue: 2
  • Publication Date: 2016
  • Doi Number: 10.5080/u12336
  • Journal Name: TURK PSIKIYATRI DERGISI
  • Journal Indexes: Social Sciences Citation Index (SSCI), Scopus, TR DİZİN (ULAKBİM)
  • Page Numbers: pp.75-83
  • Keywords: Alcoholism, OPRM1, Single Nucleotide Polymorphisms, Genetics, SUBJECTIVE RESPONSES, MOLECULAR-BIOLOGY, OPIATE ADDICTION, DRUG-DEPENDENCE, MALE TWINS, ASSOCIATION, VARIANTS, CONSUMPTION, POPULATION, BEHAVIOR
  • Hacettepe University Affiliated: Yes

Abstract

Objectives: Previous investigations on opioid system genetics have identified polymorphisms of the OPRM1 gene expressing mu-opioid receptors to be significantly associated with some features of alcohol dependence (AD). In the present study, we evaluated the relationship between single nucleotide polymorphisms (SNP) in the OPRM1 gene, A118G (rs1799971, Asn40Asp) and C17T (rs1799972, Arg6Val), and AD diagnosis, level of alcohol consumption, and AD severity in a Turkish sample.