The involvement of nitric oxide in the physiopathology of hepatoportal sclerosis


Purnak T. , Beyazit Y., Ibis M., Koklu S. , Efe C., Ozaslan E., ...More

CLINICAL BIOCHEMISTRY, vol.45, pp.1450-1454, 2012 (Journal Indexed in SCI) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 45
  • Publication Date: 2012
  • Doi Number: 10.1016/j.clinbiochem.2012.07.091
  • Title of Journal : CLINICAL BIOCHEMISTRY
  • Page Numbers: pp.1450-1454

Abstract

Background and aim: Hepatoportal sclerosis (HPS) is a clinical syndrome of unspecified etiology depicted by enlarged spleen and portal hypertension in the lack of other chronic liver disease findings, hematological disorders or any infectious disease in the liver. Nitric oxide (NO) molecule has many important functions in human body including phagocytosis in macrophages, neural transmission and endothelial relaxation. Although there is no data in literature that depicts the role of NO in HPS pathogenesis, this study was conducted in order to evaluate the potential role of NO in patients with HPS.