Testicular germ cell tumors in childhood: Treatment results of 52 patients


Guler E., Kutluk M., Buyukpamukcu N. , Caglar M. , Varan A., Akyuz C. , ...More

PEDIATRIC HEMATOLOGY AND ONCOLOGY, vol.21, no.1, pp.49-56, 2004 (Journal Indexed in SCI) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 21 Issue: 1
  • Publication Date: 2004
  • Doi Number: 10.1080/08880010490263632
  • Title of Journal : PEDIATRIC HEMATOLOGY AND ONCOLOGY
  • Page Numbers: pp.49-56

Abstract

We analysed the treatment results of 52 children with testicular germ cell tumors. Histopathological diagnoses were endodermal sinus tumor (63.4%), embryonal carcinoma (28.8%), teratocarcinoma (5.7%), and mixed tumors (2.1%). Radical inguinal orchiectomy was performed in 42 patients and retroperitoneal lymph node dissection in 10 (3/10 positive). Overall survival rates were: whole group: 71.2%; stage I: 89.7%; II: 68.5%; III: 31.2%; IV: 30% ( p = .001). Five-year overall survival rates were 85.8% and 100% for stage I patients who received chemotherapy or not ( p = .27); BEP regimen: 85.7%; classical VAC: 67.9%; vinblastine + bleomycin: 63.6%. Chemotherapy is not required in stage I. BEP regimen is effective in testicular germ cell tumors.