Testicular germ cell tumors in childhood: Treatment results of 52 patients
PEDIATRIC HEMATOLOGY AND ONCOLOGY, vol.21, no.1, pp.49-56, 2004 (SCI-Expanded, Scopus)
- Publication Type: Article / Article
- Volume: 21 Issue: 1
- Publication Date: 2004
- Doi Number: 10.1080/08880010490263632
- Journal Name: PEDIATRIC HEMATOLOGY AND ONCOLOGY
- Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
- Page Numbers: pp.49-56
- Hacettepe University Affiliated: Yes
Abstract
We analysed the treatment results of 52 children with testicular germ cell tumors. Histopathological diagnoses were endodermal sinus tumor (63.4%), embryonal carcinoma (28.8%), teratocarcinoma (5.7%), and mixed tumors (2.1%). Radical inguinal orchiectomy was performed in 42 patients and retroperitoneal lymph node dissection in 10 (3/10 positive). Overall survival rates were: whole group: 71.2%; stage I: 89.7%; II: 68.5%; III: 31.2%; IV: 30% ( p = .001). Five-year overall survival rates were 85.8% and 100% for stage I patients who received chemotherapy or not ( p = .27); BEP regimen: 85.7%; classical VAC: 67.9%; vinblastine + bleomycin: 63.6%. Chemotherapy is not required in stage I. BEP regimen is effective in testicular germ cell tumors.