Testicular germ cell tumors in childhood: Treatment results of 52 patients

Guler E., Kutluk M., Buyukpamukcu N., Caglar M., Varan A., Akyuz C., ...Daha Fazla

PEDIATRIC HEMATOLOGY AND ONCOLOGY, cilt.21, sa.1, ss.49-56, 2004 (SCI-Expanded) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 21 Sayı: 1
  • Basım Tarihi: 2004
  • Doi Numarası: 10.1080/08880010490263632
  • Dergi Adı: PEDIATRIC HEMATOLOGY AND ONCOLOGY
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Sayfa Sayıları: ss.49-56
  • Hacettepe Üniversitesi Adresli: Evet

Özet

We analysed the treatment results of 52 children with testicular germ cell tumors. Histopathological diagnoses were endodermal sinus tumor (63.4%), embryonal carcinoma (28.8%), teratocarcinoma (5.7%), and mixed tumors (2.1%). Radical inguinal orchiectomy was performed in 42 patients and retroperitoneal lymph node dissection in 10 (3/10 positive). Overall survival rates were: whole group: 71.2%; stage I: 89.7%; II: 68.5%; III: 31.2%; IV: 30% ( p = .001). Five-year overall survival rates were 85.8% and 100% for stage I patients who received chemotherapy or not ( p = .27); BEP regimen: 85.7%; classical VAC: 67.9%; vinblastine + bleomycin: 63.6%. Chemotherapy is not required in stage I. BEP regimen is effective in testicular germ cell tumors.