Fused 1,4-dihydropyridines as potential calcium modulatory compounds
MINI-REVIEWS IN MEDICINAL CHEMISTRY, cilt.6, sa.7, ss.747-755, 2006 (SCI-Expanded, Scopus)
- Yayın Türü: Makale / Derleme
- Cilt numarası: 6 Sayı: 7
- Basım Tarihi: 2006
- Doi Numarası: 10.2174/138955706777698606
- Dergi Adı: MINI-REVIEWS IN MEDICINAL CHEMISTRY
- Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
- Sayfa Sayıları: ss.747-755
- Hacettepe Üniversitesi Adresli: Evet
Özet
1,4-Dihydropyridine (1,4-DHP) derivatives nifedipine of which the prototype, are the most popular drugs having calcium an tagonistic activity. Fused 1,4-dihydropyridines (DHP's) have also exhibit calcium modulatory activities. In this article, we emphasize calcium channels and fused 1,4-DHP derivatives affecting calcium channels, fit addition, the basic considerations of synthesis, metabolism, structure-activity relationships and the latest developments on fused 1,4-DHP derivatives will be reviewed. This review also has extended examples of fused 1,4-DHP derivatives having cited activities synthesized by our group.