Fused 1,4-dihydropyridines as potential calcium modulatory compounds


Safak C. , Simsek R.

MINI-REVIEWS IN MEDICINAL CHEMISTRY, vol.6, no.7, pp.747-755, 2006 (Journal Indexed in SCI) identifier identifier

  • Publication Type: Article / Review
  • Volume: 6 Issue: 7
  • Publication Date: 2006
  • Doi Number: 10.2174/138955706777698606
  • Title of Journal : MINI-REVIEWS IN MEDICINAL CHEMISTRY
  • Page Numbers: pp.747-755

Abstract

1,4-Dihydropyridine (1,4-DHP) derivatives nifedipine of which the prototype, are the most popular drugs having calcium an tagonistic activity. Fused 1,4-dihydropyridines (DHP's) have also exhibit calcium modulatory activities. In this article, we emphasize calcium channels and fused 1,4-DHP derivatives affecting calcium channels, fit addition, the basic considerations of synthesis, metabolism, structure-activity relationships and the latest developments on fused 1,4-DHP derivatives will be reviewed. This review also has extended examples of fused 1,4-DHP derivatives having cited activities synthesized by our group.