Fused 1,4-dihydropyridines as potential calcium modulatory compounds

Safak C., Simsek R.

MINI-REVIEWS IN MEDICINAL CHEMISTRY, vol.6, no.7, pp.747-755, 2006 (SCI-Expanded) identifier identifier


1,4-Dihydropyridine (1,4-DHP) derivatives nifedipine of which the prototype, are the most popular drugs having calcium an tagonistic activity. Fused 1,4-dihydropyridines (DHP's) have also exhibit calcium modulatory activities. In this article, we emphasize calcium channels and fused 1,4-DHP derivatives affecting calcium channels, fit addition, the basic considerations of synthesis, metabolism, structure-activity relationships and the latest developments on fused 1,4-DHP derivatives will be reviewed. This review also has extended examples of fused 1,4-DHP derivatives having cited activities synthesized by our group.