Electrochemical oxidation of sildenafil citrate (Viagra) on carbon electrodes

Ozkan S., Uslu B., Zuman P.

ANALYTICA CHIMICA ACTA, cilt.501, sa.2, ss.227-233, 2004 (SCI-Expanded) identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 501 Sayı: 2
  • Basım Tarihi: 2004
  • Doi Numarası: 10.1016/j.aca.2003.09.033
  • Dergi Adı: ANALYTICA CHIMICA ACTA
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Sayfa Sayıları: ss.227-233
  • Hacettepe Üniversitesi Adresli: Hayır

Özet

In aqueous solutions containing 30% (v/v) acetonitrile the unprotonated form of the piperazine ring of sildenafil (I) is oxidized on a glassy carbon electrode between pH 2 and 8. Whereas citrate anions under conditions used are not oxidized, the oxidation pattern of sulfonamides differs from that of sildenafil (I). On the other hand, the oxidation of I resembles that of the oxidation of piperazine ring in nefazodone (III) and trazodone (IV). A more positive peak of sildenafil corresponds to an adsorption-desorption process. Measurement of the peak current enables rapid determination of sildenafil (I) in pharmaceutical preparations with sufficient accuracy. (C) 2003 Elsevier B.V. All rights reserved.