Electrochemical oxidation of sildenafil citrate (Viagra) on carbon electrodes

Ozkan S., Uslu B., Zuman P.

ANALYTICA CHIMICA ACTA, vol.501, no.2, pp.227-233, 2004 (SCI-Expanded) identifier identifier

  • Publication Type: Article / Article
  • Volume: 501 Issue: 2
  • Publication Date: 2004
  • Doi Number: 10.1016/j.aca.2003.09.033
  • Journal Name: ANALYTICA CHIMICA ACTA
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Page Numbers: pp.227-233
  • Hacettepe University Affiliated: No

Abstract

In aqueous solutions containing 30% (v/v) acetonitrile the unprotonated form of the piperazine ring of sildenafil (I) is oxidized on a glassy carbon electrode between pH 2 and 8. Whereas citrate anions under conditions used are not oxidized, the oxidation pattern of sulfonamides differs from that of sildenafil (I). On the other hand, the oxidation of I resembles that of the oxidation of piperazine ring in nefazodone (III) and trazodone (IV). A more positive peak of sildenafil corresponds to an adsorption-desorption process. Measurement of the peak current enables rapid determination of sildenafil (I) in pharmaceutical preparations with sufficient accuracy. (C) 2003 Elsevier B.V. All rights reserved.