Isolation of potential liver x receptor alpha agonist and antioxidant compounds from Hypericum microcalycinum Boiss. & Heldr.

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Aydin S. S., KUTLUAY V. M., Makino T., Inoue M., HARPUT Ü. Ş., SARAÇOĞLU İ.

ISTANBUL JOURNAL OF PHARMACY, cilt.51, sa.1, ss.98-104, 2021 (ESCI) identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 51 Sayı: 1
  • Basım Tarihi: 2021
  • Doi Numarası: 10.26650/istanbuljpharm.2020.0066
  • Dergi Adı: ISTANBUL JOURNAL OF PHARMACY
  • Derginin Tarandığı İndeksler: Emerging Sources Citation Index (ESCI)
  • Sayfa Sayıları: ss.98-104
  • Hacettepe Üniversitesi Adresli: Evet

Özet

Background and Aims: Hypericum microcalycinum Boiss. & Heldr. is used for inflammatory diseases in Anatolia. The involve-ment of liver X receptors (LXRs) and free radicals in inflammatory diseases, activation of LXRs, and high radical contents in cancerous tissue and organs prompted us to determine the radical scavenging and LXR alpha agonist activity of aqueous fraction of methanol extract and fractions of H. microcalycinum along with the isolation studies from active fractions.