Efficacy of adjuvant aromatase inhibitor in hormone receptor-positive postmenopausal breast cancer patients according to the body mass index

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Sendur M. A. N., Aksoy S., Zengin N., Altundag K.

BRITISH JOURNAL OF CANCER, vol.107, no.11, pp.1815-1819, 2012 (SCI-Expanded) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 107 Issue: 11
  • Publication Date: 2012
  • Doi Number: 10.1038/bjc.2012.473
  • Journal Name: BRITISH JOURNAL OF CANCER
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Page Numbers: pp.1815-1819
  • Hacettepe University Affiliated: Yes

Abstract

BACKGROUND: Increased adiposity may trigger signalling pathways that induce aromatase expression. As aromatase inhibitors exert their effects by blocking the aromatase enzyme, higher body mass index (BMI) can reduce the effect of aromatase inhibitors. Thus, we aimed to investigate retrospectively the effect of BMI on the efficacy of aromatase inhibitors in hormone receptor-positive postmenopausal patients with breast cancer.