Role of ace gene polymorphism in the development of angioedema secondary to angiotensin converting enzyme inhibitors and angiotensin II receptor blockers


Gulec M., Caliskaner Z., Tunca Y., Ozturk S., Bozoglu E., Gul D., ...More

ALLERGOLOGIA ET IMMUNOPATHOLOGIA, vol.36, no.3, pp.134-140, 2008 (Peer-Reviewed Journal) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 36 Issue: 3
  • Publication Date: 2008
  • Doi Number: 10.1016/s0301-0546(08)72537-0
  • Journal Name: ALLERGOLOGIA ET IMMUNOPATHOLOGIA
  • Journal Indexes: Science Citation Index Expanded, Scopus
  • Page Numbers: pp.134-140

Abstract

Background: Angiotensin Converting Enzyme inhibitors (ACEi) may cause angioedema, with an incidence of 0.1% to 1%, which may be life-threatening. ACEi induce angioedema by increasing the levels of bradykinin. Angiotensin II receptor blockers (ATRB), have a pharmacological profile similar to ACEi. The polymorphism of the ACE gene is based on the presence or absence of a 287-bp element on intron 16 on chromosome 17. The plasma level of ACE is related to gene polymorphism. ACE level in genotype DD is double that in genotype II.