Role of ace gene polymorphism in the development of angioedema secondary to angiotensin converting enzyme inhibitors and angiotensin II receptor blockers


Gulec M., Caliskaner Z., Tunca Y., Ozturk S. , Bozoglu E., Gul D., ...Daha Fazla

ALLERGOLOGIA ET IMMUNOPATHOLOGIA, cilt.36, ss.134-140, 2008 (SCI İndekslerine Giren Dergi) identifier identifier identifier

  • Cilt numarası: 36 Konu: 3
  • Basım Tarihi: 2008
  • Doi Numarası: 10.1016/s0301-0546(08)72537-0
  • Dergi Adı: ALLERGOLOGIA ET IMMUNOPATHOLOGIA
  • Sayfa Sayıları: ss.134-140

Özet

Background: Angiotensin Converting Enzyme inhibitors (ACEi) may cause angioedema, with an incidence of 0.1% to 1%, which may be life-threatening. ACEi induce angioedema by increasing the levels of bradykinin. Angiotensin II receptor blockers (ATRB), have a pharmacological profile similar to ACEi. The polymorphism of the ACE gene is based on the presence or absence of a 287-bp element on intron 16 on chromosome 17. The plasma level of ACE is related to gene polymorphism. ACE level in genotype DD is double that in genotype II.