Role of ace gene polymorphism in the development of angioedema secondary to angiotensin converting enzyme inhibitors and angiotensin II receptor blockers

---

Copy For Citation

Gulec M., Caliskaner Z., Tunca Y., Ozturk S., Bozoglu E., Gul D., ...More

ALLERGOLOGIA ET IMMUNOPATHOLOGIA, vol.36, no.3, pp.134-140, 2008 (SCI-Expanded)

• Publication Type: Article / Article
• Volume: 36 Issue: 3
• Publication Date: 2008
• Doi Number: 10.1016/s0301-0546(08)72537-0
• Journal Name: ALLERGOLOGIA ET IMMUNOPATHOLOGIA
• Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
• Page Numbers: pp.134-140
• Hacettepe University Affiliated: Yes

Abstract

Background: Angiotensin Converting Enzyme inhibitors (ACEi) may cause angioedema, with an incidence of 0.1% to 1%, which may be life-threatening. ACEi induce angioedema by increasing the levels of bradykinin. Angiotensin II receptor blockers (ATRB), have a pharmacological profile similar to ACEi. The polymorphism of the ACE gene is based on the presence or absence of a 287-bp element on intron 16 on chromosome 17. The plasma level of ACE is related to gene polymorphism. ACE level in genotype DD is double that in genotype II.