Role of ace gene polymorphism in the development of angioedema secondary to angiotensin converting enzyme inhibitors and angiotensin II receptor blockers

Gulec, M.; Caliskaner, Z.; Tunca, Y.; Ozturk, TUNCER; Bozoglu, E.; Gul, D.; Erel, F.; Kartal, O.; Karaayvaz, M.

doi:10.1016/s0301-0546(08)72537-0

Role of ace gene polymorphism in the development of angioedema secondary to angiotensin converting enzyme inhibitors and angiotensin II receptor blockers

Gulec M., Caliskaner Z., Tunca Y., Ozturk S., Bozoglu E., Gul D., ...Daha Fazla

ALLERGOLOGIA ET IMMUNOPATHOLOGIA, cilt.36, sa.3, ss.134-140, 2008 (SCI-Expanded, Scopus)

Yayın Türü: Makale / Tam Makale
Cilt numarası: 36 Sayı: 3
Basım Tarihi: 2008
Doi Numarası: 10.1016/s0301-0546(08)72537-0
Dergi Adı: ALLERGOLOGIA ET IMMUNOPATHOLOGIA
Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
Sayfa Sayıları: ss.134-140
Hacettepe Üniversitesi Adresli: Evet

Özet

Background: Angiotensin Converting Enzyme inhibitors (ACEi) may cause angioedema, with an incidence of 0.1% to 1%, which may be life-threatening. ACEi induce angioedema by increasing the levels of bradykinin. Angiotensin II receptor blockers (ATRB), have a pharmacological profile similar to ACEi. The polymorphism of the ACE gene is based on the presence or absence of a 287-bp element on intron 16 on chromosome 17. The plasma level of ACE is related to gene polymorphism. ACE level in genotype DD is double that in genotype II.