Cardiac Resynchronization Therapy Induces Adaptive Metabolic Transitions in the Metabolomic Profile of Heart Failure

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Nemutlu E., Zhang S., XU Y., TERZIC A., ZHONG L., DZEJA P. D., ...More

JOURNAL OF CARDIAC FAILURE, vol.21, no.6, pp.460-469, 2015 (SCI-Expanded) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 21 Issue: 6
  • Publication Date: 2015
  • Doi Number: 10.1016/j.cardfail.2015.04.005
  • Journal Name: JOURNAL OF CARDIAC FAILURE
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Page Numbers: pp.460-469
  • Keywords: Heart failure, metabolism, cardiac resynchronization therapy, MYOCARDIAL BLOOD-FLOW, SUBSTRATE METABOLISM, OXYGEN-CONSUMPTION, ACID-METABOLISM, IDENTIFICATION, REVEALS, HUMANS, SPECTROSCOPY, DYSSYNCHRONY, MODULATION
  • Hacettepe University Affiliated: Yes

Abstract

Background: Heart failure (HF) is associated with ventricular dyssynchrony and energetic inefficiency, which can be alleviated by cardiac resynchronization therapy (CRT). The aim of this study was to determine the metabolomic signature in HF and its prognostic value regarding the response to CRT.