Current therapeutic options for managing familial Mediterranean fever


Batu E. D. , Arici Z. S. , BİLGİNER Y. , ÖZEN S.

EXPERT OPINION ON ORPHAN DRUGS, cilt.3, ss.1063-1073, 2015 (SCI İndekslerine Giren Dergi) identifier identifier

  • Cilt numarası: 3 Konu: 9
  • Basım Tarihi: 2015
  • Doi Numarası: 10.1517/21678707.2015.1073149
  • Dergi Adı: EXPERT OPINION ON ORPHAN DRUGS
  • Sayfa Sayıları: ss.1063-1073

Özet

Introduction: Familial Mediterranean fever (FMF) is a monogenic autoinflammatory disease characterized by recurrent attacks of fever and serositis. Although colchicine prevents the recurrence of FMF attacks and the development of secondary amyloidosis, the major long-term complication of FMF in most of the patients; 5 - 10% of patients may have inadequate symptom control despite good adherence to colchicine in maximally tolerated doses.