EXPERT OPINION ON ORPHAN DRUGS, cilt.3, sa.9, ss.1063-1073, 2015 (SCI-Expanded)
Introduction: Familial Mediterranean fever (FMF) is a monogenic autoinflammatory disease characterized by recurrent attacks of fever and serositis. Although colchicine prevents the recurrence of FMF attacks and the development of secondary amyloidosis, the major long-term complication of FMF in most of the patients; 5 - 10% of patients may have inadequate symptom control despite good adherence to colchicine in maximally tolerated doses.