EXPERT OPINION ON ORPHAN DRUGS, vol.3, no.9, pp.1063-1073, 2015 (Journal Indexed in SCI)
Article / Review
Title of Journal :
EXPERT OPINION ON ORPHAN DRUGS
amyloidosis, anti-IL-1, colchicine, familial Mediterranean fever, treatment, COLCHICINE-RESISTANT, SUBCLINICAL INFLAMMATION, RECEIVING COLCHICINE, INTERFERON-ALPHA, PATIENT, CHILDREN, ANAKINRA, AMYLOIDOSIS, INFLIXIMAB, EFFICACY
Introduction: Familial Mediterranean fever (FMF) is a monogenic autoinflammatory disease characterized by recurrent attacks of fever and serositis. Although colchicine prevents the recurrence of FMF attacks and the development of secondary amyloidosis, the major long-term complication of FMF in most of the patients; 5 - 10% of patients may have inadequate symptom control despite good adherence to colchicine in maximally tolerated doses.