The protective role of ferulic acid on sepsis-induced oxidative damage in Wistar albino rats

BACANLI M., Aydin S., Taner G., Goktas H. G., Sahin T., BAŞARAN A. N., ...Daha Fazla

ENVIRONMENTAL TOXICOLOGY AND PHARMACOLOGY, cilt.38, sa.3, ss.774-782, 2014 (SCI-Expanded) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 38 Sayı: 3
  • Basım Tarihi: 2014
  • Doi Numarası: 10.1016/j.etap.2014.08.018
  • Dergi Adı: ENVIRONMENTAL TOXICOLOGY AND PHARMACOLOGY
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Sayfa Sayıları: ss.774-782
  • Anahtar Kelimeler: Sepsis, DNA damage, Alkaline single cell electrophoresis, Ferulic acid, INDUCED DNA-DAMAGE, CELLULAR STRESS-RESPONSE, GRAM-NEGATIVE SEPSIS, LIPID-PEROXIDATION, IN-VITRO, CECAL LIGATION, ANTIOXIDANT STATUS, HUMAN-LYMPHOCYTES, MITOCHONDRIAL DYSFUNCTION, COGNITIVE IMPAIRMENT
  • Hacettepe Üniversitesi Adresli: Evet

Özet

Oxidative stress has an important role in the development of sepsis-induced multiorgan failure. Ferulic acid (FA), a well-established natural antioxidant, has several pharmacological activities including anti-inflammatory, anticancer and hepatoprotective. This study aimed to investigate the effects of FA on sepsis-induced oxidative damage in Wistar albino rats. Sepsis-induced DNA damage in the lymphocytes, liver and kidney cells of rats were evaluated by comet assay with and without formamidopyrimidine DNA glycosylase (Fpg). The oxidative stress parameters such as superoxide dismutase (SOD) and glutathione peroxidase (GSH-Px) activities and total glutathione (GSH) and malondialdehyde (MDA) levels were also measured. It is found that DNA damage in sepsis + FA-treated group was significantly lower than the sepsis group. FA treatment also decreased the MDA levels and increased the GSH levels and SOD and GSH-Px activities in the sepsis-induced rats. It seems that FA might have ameliorative effects against sepsis-induced oxidative damage. (C) 2014 Published by Elsevier B.V.