Akademik Veri Yönetim Sistemi
Turkish Journal of Gastroenterology, cilt.11, sa.1, ss.39-44, 2000 (Scopus)
Ulcerative colitis is a chronic inflammatory disorder of unknown cause which is only rarely complicated by chronic amebic colitis in the western world. The aim of this clinical study was to determine the significance of p- ANCA positivity in differentiating amebic colitis from ulcerative colitis complicated by chronic amebic colitis. During a two-year period, between 1995-1997, a total of 95 patients including 16 patients with ulcerative colitis (UC), 20 patients with UC complicated by chronic amebic colitis (CAC and UC), 28 patients with pure amebic colitis (AC), 11 patients with infectious enteritis (IE) and 20 patients with irritable bowel syndrome were seen and evaluated with all available radiologic, serologic, immunologic, microbiologic (parasitologic), and pathologic studies. In eight patients with UC and 12 patients with chronic amebic colitis as an initial diagnosis complete remission could not be accomplished by a vigorous treatment regimen. In those 20 patients, a co-existing ulcerative colitis and amebic colitis was suspected. (CAC and UC). In order to differentiate these and evaluate their diagnostic value, serum p-ANCA was tested in those 20 and the remaining 75 patients in addition to performance of radiologic, histologic and serologic tests. The rates of p-ANCA positivity were as follows: 62.5% for UC, 65 % for UC complicated with CAC, 14.2 % for pure CAC, and 0% for irritable bowel syndrome and infectious enteritis. The differences of p-ANCA positivity rates were significant in patients with UC and UC complicated with CAC in comparison by pure CAC, infectious enteritis and irritable bowel syndrome (p<0.05). p-ANCA can be used as a serological marker in differentiating amebic colitis from ulcerative colitis complicated by amebic colitis. This test should be used in countries where amebic colitis is endemic.