Report of an international survey of molecular genetic testing laboratories


McGovern M. M. , Elles R., Beretta I., Somerville M. J. , Hoefler G., Keinanen M., ...Daha Fazla

COMMUNITY GENETICS, cilt.10, ss.123-131, 2007 (SCI İndekslerine Giren Dergi) identifier identifier identifier

  • Cilt numarası: 10 Konu: 3
  • Basım Tarihi: 2007
  • Doi Numarası: 10.1159/000101753
  • Dergi Adı: COMMUNITY GENETICS
  • Sayfa Sayıları: ss.123-131

Özet

Objective: To collect data on the practices of molecular genetic testing (MGT) laboratories for the development of national and international policies for quality assurance (QA). Methods: A web-based survey of MGT laboratory directors (n = 827; response rate 63%) in 18 countries on 3 continents. QA and reporting indices were developed and calculated for each responding laboratory. Results: Laboratory setting varied among and within countries, as did qualifications of the directors. Respondents in every country indicated that their laboratory receives specimens from outside their national borders (64%, n = 529). Pair-wise comparisons of the QA index revealed a significant association with the director having formal training in molecular genetics (p < 0.005), affiliation with a genetics unit (p = 0.003), accreditation of the laboratory (p < 0.005) and participation in proficiency testing (p < 0.005). Research labs had a lower mean report score compared to all other settings (p < 0.05) as did laboratories accessioning <150 samples per year. Conclusion: MGT is provided under widely varying conditions and regulatory frameworks. The data provided here may be a useful guide for policy action at both governmental and professional levels.