PLGA/Silane-modified bioactive glass/nanocellulose composite scaffolds: structure–property relationships
Polymer Bulletin, cilt.83, sa.9, 2026 (SCI-Expanded, Scopus)
- Yayın Türü: Makale / Tam Makale
- Cilt numarası: 83 Sayı: 9
- Basım Tarihi: 2026
- Doi Numarası: 10.1007/s00289-026-06447-w
- Dergi Adı: Polymer Bulletin
- Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus, Chemical Abstracts Core, Chimica, Compendex, INSPEC, Academic Search Ultimate (EBSCO), Engineering Source (EBSCO), Materials Science & Engineering Collection (ProQuest), Technology Collection (ProQuest)
- Açık Arşiv Koleksiyonu: AVESİS Açık Erişim Koleksiyonu
- Hacettepe Üniversitesi Adresli: Evet
Özet
This paper reports the design and characterization of poly(lactic-co-glycolic) acid (PLGA) based composite scaffolds reinforced with silane-modified bioactive glass (sBG) and nanocellulose (NC), aimed at improving the structure–property balance required for scaffold applications. The purpose of this approach was to combine the favorable mechanical and bioactivity characteristics of the additives with the beneficial properties of the copolymer. While binary PLGA/sBG systems have been previously investigated, the synergistic effects arising from simultaneous incorporation of both sBG and NC in a ternary PLGA/sBG/NC scaffold have not yet been demonstrated. Scaffolds were produced using a solvent casting/particle leaching method, yielding well-interconnected porous structures as confirmed by scanning electron microscopy and porosity measurements. Among all formulations PLGA/20sBG/15NC ternary scaffold had the highest compressive strength and Young’s modulus, measured as 15.06 MPa and 0.50 MPa, respectively. The ternary composition exhibited a porosity of approximately 68%, which is the smallest value among the other composites. The addition of sBG enhanced apatite formation, whereas NC promoted hydrolytic degradation. Preliminary cytocompatibility assessments confirmed that all scaffold formulations were non-cytotoxic. These results demonstrate that incorporating sBG and NC into PLGA provides a balanced enhancement of mechanical integrity, bioactivity, and degradation, making the composite a promising candidate for polymer-based scaffold applications.