A weighted rule based method for predicting malignancy of pulmonary nodules by nodule characteristics


JOURNAL OF BIOMEDICAL INFORMATICS, vol.56, pp.69-79, 2015 (SCI-Expanded) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 56
  • Publication Date: 2015
  • Doi Number: 10.1016/j.jbi.2015.05.011
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Page Numbers: pp.69-79
  • Keywords: Nodule characteristic, Ensemble classifier, Rule based classification, Unbalanced data, CLASSIFICATION, LUNG, CT
  • Hacettepe University Affiliated: Yes


Predicting malignancy of solitary pulmonary nodules from computer tomography scans is a difficult and important problem in the diagnosis of lung cancer. This paper investigates the contribution of nodule characteristics in the prediction of malignancy. Using data from Lung Image Database Consortium (LIDC) database, we propose a weighted rule based classification approach for predicting malignancy of pulmonary nodules. LIDC database contains CT scans of nodules and information about nodule characteristics evaluated by multiple annotators. In the first step of our method, votes for nodule characteristics are obtained from ensemble classifiers by using image features. In the second step, votes and rules obtained from radiologist evaluations are used by a weighted rule based method to predict malignancy. The rule based method is constructed by using radiologist evaluations on previous cases. Correlations between malignancy and other nodule characteristics and agreement ratio of radiologists are considered in rule evaluation. To handle the unbalanced nature of LIDC, ensemble classifiers and data balancing methods are used. The proposed approach is compared with the classification methods trained on image features. Classification accuracy, specificity and sensitivity of classifiers are measured. The experimental results show that using nodule characteristics for malignancy prediction can improve classification results. (C) 2015 Elsevier Inc. All rights reserved.