Cathepsin S deficiency confers protection from neonatal hyperoxia-induced lung injury

HIRAKAWA H., PIERCE R. A., BINGOL-KARAKOC G., Karaaslan C., WENG M., SHI G., ...Daha Fazla

AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE, cilt.176, sa.8, ss.778-785, 2007 (SCI-Expanded) identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 176 Sayı: 8
  • Basım Tarihi: 2007
  • Doi Numarası: 10.1164/rccm.200704-5190c
  • Dergi Adı: AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Sayfa Sayıları: ss.778-785
  • Anahtar Kelimeler: cathepsin, bronchopulmonary dysplasia, hyperoxia, myofibroblast, LOW-BIRTH-WEIGHT, CYSTEINE PROTEASES, BRONCHOPULMONARY DYSPLASIA, PULMONARY-FIBROSIS, PRETERM LAMBS, BABOON MODEL, RAT LUNG, APOPTOSIS, EXPRESSION, ATHEROSCLEROSIS
  • Hacettepe Üniversitesi Adresli: Evet

Özet

Rationale Bronchopulmonary dysplasia (BPD) is a chronic lung disease that adversely affects long-term pulmonary function as well as neurodevelopmental outcomes of preterm infants. Elastolytic proteases have been implicated in the pathogenesis of BPD. Cathepsin S (cat S) is a cysteine protease with potent elastolytic activity. Increased levels and activity of cat S have been detected in a baboon model of BPD.