Cathepsin S deficiency confers protection from neonatal hyperoxia-induced lung injury
AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE, vol.176, no.8, pp.778-785, 2007 (SCI-Expanded, Scopus)
- Publication Type: Article / Article
- Volume: 176 Issue: 8
- Publication Date: 2007
- Doi Number: 10.1164/rccm.200704-5190c
- Journal Name: AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE
- Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
- Page Numbers: pp.778-785
- Keywords: cathepsin, bronchopulmonary dysplasia, hyperoxia, myofibroblast, LOW-BIRTH-WEIGHT, CYSTEINE PROTEASES, BRONCHOPULMONARY DYSPLASIA, PULMONARY-FIBROSIS, PRETERM LAMBS, BABOON MODEL, RAT LUNG, APOPTOSIS, EXPRESSION, ATHEROSCLEROSIS
- Hacettepe University Affiliated: Yes
Abstract
Rationale Bronchopulmonary dysplasia (BPD) is a chronic lung disease that adversely affects long-term pulmonary function as well as neurodevelopmental outcomes of preterm infants. Elastolytic proteases have been implicated in the pathogenesis of BPD. Cathepsin S (cat S) is a cysteine protease with potent elastolytic activity. Increased levels and activity of cat S have been detected in a baboon model of BPD.