Cathepsin S deficiency confers protection from neonatal hyperoxia-induced lung injury


HIRAKAWA H. , PIERCE R. A. , BINGOL-KARAKOC G., Karaaslan C., WENG M., SHI G., ...Daha Fazla

AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE, cilt.176, ss.778-785, 2007 (SCI İndekslerine Giren Dergi) identifier identifier

  • Cilt numarası: 176 Konu: 8
  • Basım Tarihi: 2007
  • Doi Numarası: 10.1164/rccm.200704-5190c
  • Dergi Adı: AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE
  • Sayfa Sayıları: ss.778-785

Özet

Rationale Bronchopulmonary dysplasia (BPD) is a chronic lung disease that adversely affects long-term pulmonary function as well as neurodevelopmental outcomes of preterm infants. Elastolytic proteases have been implicated in the pathogenesis of BPD. Cathepsin S (cat S) is a cysteine protease with potent elastolytic activity. Increased levels and activity of cat S have been detected in a baboon model of BPD.