Cancer stemness as a target for immunotherapy is shaped by pro-inflammatory stress.

Unver N.

Current stem cell research & therapy, cilt.16, ss.792-800, 2021 (SCI-Expanded) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 16
  • Basım Tarihi: 2021
  • Doi Numarası: 10.2174/1574888x15666200309145901
  • Dergi Adı: Current stem cell research & therapy
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus, BIOSIS, Biotechnology Research Abstracts, Chemical Abstracts Core, EMBASE, MEDLINE
  • Sayfa Sayıları: ss.792-800
  • Anahtar Kelimeler: Inflammation, cancer stemness, pro-inflammatory stress, cancer stem cells, pro-inflammatory cytokines, immuno-therapeutic strategies, T-CELLS, MESENCHYMAL TRANSITION, INITIATING CELLS, DENDRITIC CELLS, GROWTH, PROMOTES, PATHWAY, NOTCH, ACTIVATION, EXPRESSION
  • Hacettepe Üniversitesi Adresli: Evet

Özet

Cancer stem cells represent a rare subpopulation of cancer cells carrying self-renewal and differentiation features in multi-step tumorigenesis, tumor recurrence and metastasis. Pro inflammatory stress is highly associated with cancer stemness via induction of cytokines, tumor promoting immune cells and cancer stemness-related signaling pathways. This review summarizes the major pro-inflammatory factors affecting cancer stem cell characteristics and the critical immunotherapeutic strategies to eliminate cancer stem cells.