Cancer stemness as a target for immunotherapy is shaped by pro-inflammatory stress.

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Unver N.

Current stem cell research & therapy, vol.16, pp.792-800, 2021 (SCI-Expanded, Scopus)

• Publication Type: Article / Article
• Volume: 16
• Publication Date: 2021
• Doi Number: 10.2174/1574888x15666200309145901
• Journal Name: Current stem cell research & therapy
• Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus, BIOSIS, Biotechnology Research Abstracts, Chemical Abstracts Core, EMBASE, MEDLINE
• Page Numbers: pp.792-800
• Keywords: Inflammation, cancer stemness, pro-inflammatory stress, cancer stem cells, pro-inflammatory cytokines, immuno-therapeutic strategies, T-CELLS, MESENCHYMAL TRANSITION, INITIATING CELLS, DENDRITIC CELLS, GROWTH, PROMOTES, PATHWAY, NOTCH, ACTIVATION, EXPRESSION
• Hacettepe University Affiliated: Yes

Abstract

Cancer stem cells represent a rare subpopulation of cancer cells carrying self-renewal and differentiation features in multi-step tumorigenesis, tumor recurrence and metastasis. Pro inflammatory stress is highly associated with cancer stemness via induction of cytokines, tumor promoting immune cells and cancer stemness-related signaling pathways. This review summarizes the major pro-inflammatory factors affecting cancer stem cell characteristics and the critical immunotherapeutic strategies to eliminate cancer stem cells.