Synthesis of some novel 3-methyl-6-(2-substituted propanoyl/propyl)-2-benzoxazolinone derivatives and anti-nociceptive activity
FARMACO, cilt.56, sa.9, ss.719-724, 2001 (SCI-Expanded)
- Yayın Türü: Makale / Tam Makale
- Cilt numarası: 56 Sayı: 9
- Basım Tarihi: 2001
- Doi Numarası: 10.1016/s0014-827x(01)01132-6
- Dergi Adı: FARMACO
- Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Index Chemicus (IC)
- Sayfa Sayıları: ss.719-724
- Hacettepe Üniversitesi Adresli: Evet
Özet
In this study, 12 new 3-methyl-6-(2-substituted aminopropanoyl)-2-benzoxazolinone and 3-methyl-6-(1-hydroxy-2-substituted aminopropyl)-2-benzoxazolinone derivatives have been prepared. Their structures have been elucidated by IR, H-1 NMR spectra and by elementary analysis. The anti-nociceptive activity of these compounds has been investigated by using a modified Koster test. It was found that most compounds are capable of inducing anti-nociception in animals. (C) 2001 Elsevier Science S.A. All rights reserved.