The immune and hemostatic systems share a common evolutionary origin, both defend against threats to organisms, and inflammation can cause venous thromboembolism. We would like to report a patient with a history of psoriasis, a chronic inflammatory disease, who has been admitted to our clinic with a swollen right arm and collateral veins visible throughout the right upper arm and right pectoral region, which have been present for almost 2 years. Investigations revealed a thrombus extending from the proximal basilic vein into the axillary and subclavian veins but sparing the superior vena cava. Further investigation was performed to reveal any likely cause other than psoriasis, including malignancy, rheumatological disease, or genetic thrombophilia, but none were revealed. This report illustrates that psoriasis-related inflammation can cause atypically located venous thromboembolic events.