Bone Morphogenetic Protein-7 Enhances Cementoblast Function In Vitro

HAKKI S., Foster B. L. , Nagatomo K. J. , Bozkurt S. B. , HAKKI E. E. , Somerman M. J. , ...Daha Fazla

JOURNAL OF PERIODONTOLOGY, cilt.81, ss.1663-1674, 2010 (SCI İndekslerine Giren Dergi) identifier identifier identifier

  • Cilt numarası: 81 Konu: 11
  • Basım Tarihi: 2010
  • Doi Numarası: 10.1902/jop.2010.100074
  • Sayfa Sayıları: ss.1663-1674


Background: Bone morphogenetic protein (BMP)-7 is a potent bone-inducing factor and was shown to promote periodontal regeneration in vivo and in vitro; however, to our knowledge, the specific effect of BMP-7 on cementoblasts has not been defined. We aimed to investigate the effects of BMP-7 on cementoblasts, which are cells responsible for tooth root-cementum formation. We hypothesized that BMP-7 would regulate mineralized tissue-associated genes in cementoblasts and influence the expression profile of genes associated with cementoblast extracellular matrix (ECM) and cell adhesion molecules (CAMs).