Chlorogenic Acid Containing Bioinspired Polyurethanes: Biodegradable Medical Adhesive Materials

ATEŞ B., KÖYTEPE S., Karaaslan M. G., Balcioglu S., Gulgen S., DEMİRBİLEK M., ...More

INTERNATIONAL JOURNAL OF POLYMERIC MATERIALS AND POLYMERIC BIOMATERIALS, vol.64, no.12, pp.611-619, 2015 (SCI-Expanded) identifier identifier


Highly adhesive bioinspired polyurethanes (PUs) based on the chlorogenic acid (CLA) were prepared from 4,4'-methylenebis (cyclohexyl isocyanate) (MCI) and polyethylene glycol 200 (PEG 200). The polyurethanes exhibited the lowest glass transition temperature (T-g), improved thermal stability and good adhesive properties. The highest adhesion strength was found as 373.3 +/- 47.5 kPa for 10% CLA containing PUs. The polyurethanes were observed to be biodegradable and were in the range of 19-24% for 8 weeks as depending on chlorogenic acid containing of PUs. As a result, prepared biocompatible-adhesive bioinspired polyurethanes are good candidates for medical applications as a tissue adhesive material.