Intracerebral metastasis in pediatric acute lymphoblastic leukemia: A rare presentation

Gokce M., Aytac Ş. S. , Altan I. , ÜNAL Ş. , Tuncer M., GÜMRÜK F. , ...More

Journal of Pediatric Neurosciences, vol.7, no.3, pp.208-210, 2012 (Journal Indexed in SCI Expanded) identifier identifier

  • Publication Type: Article / Article
  • Volume: 7 Issue: 3
  • Publication Date: 2012
  • Doi Number: 10.4103/1817-1745.106482
  • Title of Journal : Journal of Pediatric Neurosciences
  • Page Numbers: pp.208-210


Central nervous system leukemia may present in different ways. However, intraparenchymal mass is extremely rare in childhood leukemia. Herein, we report a boy who presented with right hemiparesis and anisocoria 1 year after the cessation of the chemotherapy protocol for acute lymphoblastic leukemia. Cranial imaging demonstrated an extensive mass located in the anterior white matter of left frontal lobe, and cerebrospinal fluid examination revealed concomitant lymphoblasts. Immunohistochemical staining of the biopsy material showed neoplastic cells with positive CD10 and TdT. Complete remission was achieved with chemotherapy alone for a duration of 2 years.