The Effects of Nitric Oxide on Rat Stomach Injury Induced by Acetylsalicylic Acid


Yagmurca M., UÇAR M., FADILLIOĞLU E. , Erdogan H., Ozturk F.

TURKISH JOURNAL OF MEDICAL SCIENCES, vol.39, no.1, pp.13-19, 2009 (Journal Indexed in SCI) identifier

  • Publication Type: Article / Article
  • Volume: 39 Issue: 1
  • Publication Date: 2009
  • Title of Journal : TURKISH JOURNAL OF MEDICAL SCIENCES
  • Page Numbers: pp.13-19

Abstract

Aim: Acetylsalicylic acid (ASA, aspirin), which is one of the most frequently used drugs in the world. causes severe gastric mucosal injury. Nitric oxide (NO) is synthesized from L-arginine by nitric oxide synthase (NOS). NOS can be inhibited by N omega-nitro-L-arginine methyl ester (L-NAME) and stimulated by supplementing the diet with L-arginine (L-Arg). The aim of this study was to investigate the role of NO on gastric mucosal injury induced by ASA.