Polyphenolic compounds of Sideritis lycia and their anti-inflammatory activity

AKCOS Y., Ezer N., Calis I., DEMIRDAMAR R., Tel B. C.

PHARMACEUTICAL BIOLOGY, vol.37, no.2, pp.118-122, 1999 (SCI-Expanded) identifier identifier

  • Publication Type: Article / Article
  • Volume: 37 Issue: 2
  • Publication Date: 1999
  • Doi Number: 10.1076/phbi.
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Page Numbers: pp.118-122
  • Hacettepe University Affiliated: Yes


Four phenylpropanoid glycosides lavandulifolioside 1, martynoside 2, verbascoside (=acteoside) 3 cmd leucosceptoside A 4, were isolated from aerial parts of Sideritis lycia Boiss. et Heldr. (Lamiaceae). Their structures were determined by chromatographic and spectroscopic methods (UV, IR, H-1-NMR, C-13-NMR, FAB-MS). These compounds and flavonoid glycosides isolated from the same plant in our previously study were screened for their anti-inflammatory activity using the carrageenan-induced mouse paw edema test. The active compounds were then investigated for their effect on gastric ulceration. Although flavonoid glycosides showed higher activity than the phenyl-propanoid glycosides, the gastric ulceration effect of phenylpropanoid glycosides was less than flavonoid glycosides.